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Ehsan Sarafraz-Yazdi Selected Research

PNC-27

4/2022PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis.
9/2020Anti-Cancer Tumor Cell Necrosis of Epithelial Ovarian Cancer Cell Lines Depends on High Expression of HDM-2 Protein in Their Membranes.
5/2017Synergy between Paclitaxel and Anti-Cancer Peptide PNC-27 in the Treatment of Ovarian Cancer.
1/2015Ex vivo Efficacy of Anti-Cancer Drug PNC-27 in the Treatment of Patient-Derived Epithelial Ovarian Cancer.
1/2014The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells.
1/2011Anti-cancer peptides from ras-p21 and p53 proteins.
7/2010The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide.
2/2010Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes.

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Ehsan Sarafraz-Yazdi Research Topics

Disease

12Neoplasms (Cancer)
04/2022 - 12/2008
5Necrosis
04/2022 - 12/2008
3Ovarian Neoplasms (Ovarian Cancer)
09/2020 - 01/2015
2Breast Neoplasms (Breast Cancer)
10/2021 - 07/2010
2Ovarian Epithelial Carcinoma
09/2020 - 01/2015
1Carcinoma (Carcinomatosis)
10/2021
1Hematologic Neoplasms (Hematological Malignancy)
09/2020
1Leukemia
01/2014
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
12/2012
1Pancreatic Neoplasms (Pancreatic Cancer)
12/2008

Drug/Important Bio-Agent (IBA)

11Peptides (Polypeptides)IBA
04/2022 - 12/2008
8PNC-27IBA
04/2022 - 02/2010
6Proteins (Proteins, Gene)FDA Link
10/2021 - 12/2008
2Pharmaceutical PreparationsIBA
01/2015 - 01/2014
2PNC-28IBA
01/2015 - 12/2008
2L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
01/2014 - 12/2008
1Cell-Penetrating PeptidesIBA
04/2022
1GoldIBA
04/2022
16-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA
04/2022
1Biological ProductsIBA
01/2022
1CytokinesIBA
10/2021
1pirfenidoneIBA
10/2021
1Protein Isoforms (Isoforms)IBA
09/2020
1Paclitaxel (Taxol)FDA LinkGeneric
05/2017
1Tumor Biomarkers (Tumor Markers)IBA
12/2016
1AntibodiesIBA
01/2014
1CaspasesIBA
01/2014
1penetratinIBA
12/2008
1Annexin A5IBA
12/2008

Therapy/Procedure

2Therapeutics
12/2016 - 01/2014
2Drug Therapy (Chemotherapy)
01/2015 - 01/2014
1Lab-On-A-Chip Devices
10/2021